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Can Anti–β-amyloid Monoclonal Antibodies Work in Autosomal Dominant Alzheimer Disease?

The dominant theory of Alzheimer disease (AD) has been that amyloid-β (Aβ) accumulation in the brain is the initial cause of the degeneration leading to cognitive and functional deficits. Autosomal dominant Alzheimer disease (ADAD), in which pathologic mutations of the amyloid precursor protein (APP...

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Bibliographic Details
Published in:Neurol Genet
Main Authors: Imbimbo, Bruno P., Lucca, Ugo, Watling, Mark
Format: Artigo
Language:Inglês
Published: Wolters Kluwer 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862085/
https://ncbi.nlm.nih.gov/pubmed/33575481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXG.0000000000000535
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