Different Fumaric Acid Esters Elicit Distinct Pharmacologic Responses

OBJECTIVE: To test the hypothesis that dimethyl fumarate (DMF, Tecfidera) elicits different biological changes from DMF combined with monoethyl fumarate (MEF) (Fumaderm, a psoriasis therapy), we investigated DMF and MEF in rodents and cynomolgus monkeys. Possible translatability of findings was expl...

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Udgivet i:Neurol Neuroimmunol Neuroinflamm
Main Authors: Wipke, Brian T., Hoepner, Robert, Strassburger-Krogias, Katrin, Thomas, Ankur M., Gianni, Davide, Szak, Suzanne, Brennan, Melanie S., Pistor, Maximilian, Gold, Ralf, Chan, Andrew, Scannevin, Robert H.
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862084/
https://ncbi.nlm.nih.gov/pubmed/33468560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000950
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