HOTAIR Induces Methylation of PCDH10, a Tumor Suppressor Gene, by Regulating DNMT1 and Sponging with miR-148b in Gastric Adenocarcinoma

PURPOSE: HOX transcript antisense intergenic RNA (HOTAIR), as a long non-coding RNA, has been reported to regulate carcinogenesis by epigenetic mechanism in various cancers. Protocadherin 10 (PCDH10) is one of the well-known tumor suppressor genes, and is frequently methylated in gastric cancers (GC...

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Publicat a:Yonsei Med J
Autors principals: Seo, Seung In, Yoon, Jung-Ho, Byun, Hyo Joo, Lee, Sang Kil
Format: Artigo
Idioma:Inglês
Publicat: Yonsei University College of Medicine 2021
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7859685/
https://ncbi.nlm.nih.gov/pubmed/33527791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3349/ymj.2021.62.2.118
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