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Activation of the Nlrp3 Inflammasome Contributes to Shiga Toxin-Induced Hemolytic Uremic Syndrome in a Mouse Model
OBJECTIVE: To explore the role of the Nlrp3 inflammasome activation in the development of hemolytic uremic syndrome (HUS) induced by Stx2 and evaluate the efficacy of small molecule Nlrp3 inhibitors in preventing the HUS. METHODS: Peritoneal macrophages (PMs) isolated from wild-type (WT) C57BL/6J mi...
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| 出版年: | Front Immunol |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Media S.A.
2021
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7859089/ https://ncbi.nlm.nih.gov/pubmed/33552083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.619096 |
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