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Modulation of Increased mGluR1 Signaling by RGS8 Protects Purkinje Cells From Dendritic Reduction and Could Be a Common Mechanism in Diverse Forms of Spinocerebellar Ataxia

Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases which are caused by diverse genetic mutations in a variety of different genes. We have identified RGS8, a regulator of G-protein signaling, as one of the genes which are dysregulated in different mouse models of SCA...

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Détails bibliographiques
Publié dans:Front Cell Dev Biol
Auteurs principaux: Wu, Qin-Wei, Kapfhammer, Josef P.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7858651/
https://ncbi.nlm.nih.gov/pubmed/33553137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.569889
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