Genome‐scale CRISPR screening identifies cell cycle and protein ubiquitination processes as druggable targets for erlotinib‐resistant lung cancer

Erlotinib is highly effective in lung cancer patients with epidermal growth factor receptor (EGFR) mutations. However, despite initial favorable responses, most patients rapidly develop resistance to erlotinib soon after the initial treatment. This study aims to identify new genes and pathways assoc...

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Vydáno v:Mol Oncol
Hlavní autoři: Lee, Jieun, Choi, Ahyoung, Cho, Sung‐Yup, Jun, Yukyung, Na, Deukchae, Lee, Ahra, Jang, Giyong, Kwon, Jee Young, Kim, Jaesang, Lee, Sanghyuk, Lee, Charles
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7858278/
https://ncbi.nlm.nih.gov/pubmed/33188726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12853
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