HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple‐negative breast cancer

Dependence on glutamine and acceleration of fatty acid oxidation (FAO) are both metabolic characteristics of triple‐negative breast cancer (TNBC). With the rapid growth of tumors, accelerated glutamine catabolism depletes local glutamine, resulting in glutamine deficiency. Studies have shown that th...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Guo, Xin, Wang, Aman, Wang, Wen, Wang, Ya, Chen, Huan, Liu, Xiaolong, Xia, Tian, Zhang, Aijia, Chen, Di, Qi, Huan, Ling, Ting, Piao, Hai‐long, Wang, Hong‐jiang
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7858277/
https://ncbi.nlm.nih.gov/pubmed/33207079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12856
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