(p)ppGpp/GTP and Malonyl-CoA Modulate Staphylococcus aureus Adaptation to FASII Antibiotics and Provide a Basis for Synergistic Bi-Therapy

Fatty acid biosynthesis (FASII) enzymes are considered valid targets for antimicrobial drug development against the human pathogen Staphylococcus aureus. However, incorporation of host fatty acids confers FASII antibiotic adaptation that compromises prospective treatments. S. aureus adapts to FASII...

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Udgivet i:mBio
Main Authors: Pathania, Amit, Anba-Mondoloni, Jamila, Gominet, Myriam, Halpern, David, Dairou, Julien, Dupont, Laëtitia, Lamberet, Gilles, Trieu-Cuot, Patrick, Gloux, Karine, Gruss, Alexandra
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7858065/
https://ncbi.nlm.nih.gov/pubmed/33531402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03193-20
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