Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels

Microbial conversion of dietary or drug substrates into small bioactive molecules represents a regulatory mechanism by which the gut microbiota alters intestinal physiology. Here, we show that a wide variety of gut bacteria can metabolize the dietary supplement and antidepressant 5-hydroxytryptophan...

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Udgivet i:PLoS Biol
Main Authors: Waclawiková, Barbora, Bullock, Amber, Schwalbe, Markus, Aranzamendi, Carmen, Nelemans, Sieger A., van Dijk, Gertjan, El Aidy, Sahar
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7857600/
https://ncbi.nlm.nih.gov/pubmed/33481771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001070
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