Hyper-truncated Asn355- and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase

Myeloperoxidase (MPO) plays essential roles in neutrophil-mediated immunity via the generation of reactive oxidation products. Complex carbohydrates decorate MPO at discrete sites, but their functional relevance remains elusive. To this end, we have characterised the structure–biosynthesis–activity...

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Vydáno v:J Biol Chem
Hlavní autoři: Tjondro, Harry C., Ugonotti, Julian, Kawahara, Rebeca, Chatterjee, Sayantani, Loke, Ian, Chen, Siyun, Soltermann, Fabian, Hinneburg, Hannes, Parker, Benjamin L., Venkatakrishnan, Vignesh, Dieckmann, Regis, Grant, Oliver C., Bylund, Johan, Rodger, Alison, Woods, Robert J., Karlsson-Bengtsson, Anna, Struwe, Weston B., Thaysen-Andersen, Morten
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7857493/
https://ncbi.nlm.nih.gov/pubmed/33273015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016342
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