Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion

Retinoblastoma protein (RB) encoded by Rb1 is a prominent inducer of cell cycle arrest (CCA). The hormone progesterone (P(4)) promotes CCA in the uterine epithelium and previous studies indicated that P(4) activates RB by reducing the phosphorylated, inactive form of RB. Here, we show that embryo im...

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Veröffentlicht in:EMBO Rep
Hauptverfasser: Akaeda, Shun, Hirota, Yasushi, Fukui, Yamato, Aikawa, Shizu, Shimizu‐Hirota, Ryoko, Kaku, Tetsuaki, Gebril, Mona, Hirata, Tomoyuki, Hiraoka, Takehiro, Matsuo, Mitsunori, Haraguchi, Hirofumi, Saito‐Kanatani, Mayuko, Takeda, Norihiko, Fujii, Tomoyuki, Osuga, Yutaka
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7857437/
https://ncbi.nlm.nih.gov/pubmed/33399260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050927
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