Improved Antiglioblastoma Activity and BBB Permeability by Conjugation of Paclitaxel to a Cell‐Penetrative MMP‐2‐Cleavable Peptide

In order to solve the problems of receptor promiscuity and poor blood‐brain barrier (BBB) penetration in the treatment of glioblastomas (GBM), a novel dual‐functional nanocomplex drug delivery system is developed based on the strategy of peptide‐drug conjugates. In this study, SynB3‐PVGLIG‐PTX is de...

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Bibliographic Details
Published in:Adv Sci (Weinh)
Main Authors: Hua, Dan, Tang, Lida, Wang, Weiting, Tang, Shengan, Yu, Lin, Zhou, Xuexia, Wang, Qian, Sun, Cuiyun, Shi, Cuijuan, Luo, Wenjun, Jiang, Zhendong, Li, Huining, Yu, Shizhu
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856885/
https://ncbi.nlm.nih.gov/pubmed/33552853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202001960
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