Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia

BACKGROUND AND AIMS: Extra-hepatic biliary atresia (BA) is a pediatric liver disease with no approved medical therapy. Recent studies using human samples and experimental modeling suggest that glutathione redox metabolism and heterogeneity play a role in disease pathogenesis. We sought to dissect th...

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Gepubliceerd in:Gastroenterology
Hoofdauteurs: Zhao, Xiao, Lorent, Kristin, Escobar-Zarate, Diana, Rajagopalan, Ramakrishnan, Loomes, Kathleen M., Gillespie, Kevin, Mesaros, Clementina, Estrada, Michelle A., Blair, Ian, Winkler, Jeffrey D., Spinner, Nancy B., Devoto, Marcella, Pack, Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856536/
https://ncbi.nlm.nih.gov/pubmed/32505743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.05.080
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