Cuprizone markedly decreases kynurenic acid levels in the rodent brain tissue and plasma

BACKGROUND: The kynurenine (KYN) pathway (KP) of the tryptophan (TRP) metabolism seems to play a role in the pathomechanism of multiple sclerosis (MS). Cuprizone (CPZ) treated animals develop both demyelination (DEM) and remyelination (REM) in lack of peripheral immune response, such as the lesion p...

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Dettagli Bibliografici
Pubblicato in:Heliyon
Autori principali: Polyák, Helga, Cseh, Edina Katalin, Bohár, Zsuzsanna, Rajda, Cecilia, Zádori, Dénes, Klivényi, Péter, Toldi, József, Vécsei, László
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856478/
https://ncbi.nlm.nih.gov/pubmed/33553777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2021.e06124
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