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Inferring protein sequence-function relationships with large-scale positive-unlabeled learning

Machine learning can infer how protein sequence maps to function without requiring a detailed understanding of the underlying physical or biological mechanisms. It’s challenging to apply existing supervised learning frameworks to large-scale experimental data generated by deep mutational scanning (D...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Song, Hyebin, Bremer, Bennett J., Hinds, Emily C., Raskutti, Garvesh, Romero, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856229/
https://ncbi.nlm.nih.gov/pubmed/33212013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.10.007
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