Exploration of bacterial bottlenecks and Streptococcus pneumoniae pathogenesis by CRISPRi-seq

Streptococcus pneumoniae is an opportunistic human pathogen that causes invasive disease, including pneumonia, with greater health risks upon influenza A virus (IAV) co-infection. To facilitate pathogenesis studies in vivo, we developed an inducible CRISPR interference system (CRISPRi-seq) that enab...

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Vydáno v:Cell Host Microbe
Hlavní autoři: Liu, Xue, Kimmey, Jacqueline M., Matarazzo, Laura, de Bakker, Vincent, Maele, Laurye Van, Sirard, Jean-Claude, Nizet, Victor, Veening, Jan-Willem
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855995/
https://ncbi.nlm.nih.gov/pubmed/33120116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.10.001
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