Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau

Amyloid aggregation of tau protein is implicated in neurodegenerative diseases, yet its facilitating factors are poorly understood. Recently, tau has been shown to undergo liquid liquid phase separation (LLPS) both in vivo and in vitro. LLPS was shown to facilitate tau amyloid aggregation in certain...

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Publicado en:J Mol Biol
Main Authors: Lin, Yanxian, Fichou, Yann, Longhini, Andrew P., Llanes, Luana C., Yin, Pengyi, Bazan, Guillermo C., Kosik, Kenneth S., Han, Songi
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855949/
https://ncbi.nlm.nih.gov/pubmed/33279579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.166731
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