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Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau
Amyloid aggregation of tau protein is implicated in neurodegenerative diseases, yet its facilitating factors are poorly understood. Recently, tau has been shown to undergo liquid liquid phase separation (LLPS) both in vivo and in vitro. LLPS was shown to facilitate tau amyloid aggregation in certain...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7855949/ https://ncbi.nlm.nih.gov/pubmed/33279579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.166731 |
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