β-Arrestin Biased Agonist Targeting the Brain Angiotensin II Type 1 Receptor Increases Aversion to Saline and Lowers Blood Pressure in DOCA-salt Hypertension

Activation of central angiotensin type 1 receptors (AT(1)R) is required for the increased blood pressure (BP), polydipsia and salt intake in deoxycorticosterone acetate (DOCA)-salt hypertension. TRV120027 (TRV027) is an AT(1)R-biased agonist that selectively acts through β-arrestin. We hypothesized...

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Publicado no:Hypertension
Main Authors: Zanaty, Mario, Seara, Fernando A. C., Nakagawa, Pablo, Deng, Guorui, Mathieu, Natalia M., Balapattabi, Kirthikaa, Karnik, Sadashiva S., Grobe, Justin L., Sigmund, Curt D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855825/
https://ncbi.nlm.nih.gov/pubmed/33249862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15793
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