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Reductive Arylation of Amides via a Nickel-Catalyzed Suzuki–Miyaura Coupling and Transfer Hydrogenation Cascade
We report a means to achieve the addition of two disparate nucleophiles to the amide carbonyl carbon in a single operational step. Our method takes advantage of non-precious metal catalysis and allows for the facile conversion of amides to chiral alcohols via a one-pot Suzuki–Miyaura cross-coupling...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7855255/ https://ncbi.nlm.nih.gov/pubmed/33029868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202012048 |
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