Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design

Enterotoxigenic Escherichia coli (ETEC) is estimated to cause approximately 380,000 deaths annually during sporadic or epidemic outbreaks worldwide. Development of vaccines against ETEC is very challenging due to the vast heterogeneity of the ETEC strains. An effective vaccines would have to be mult...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Amcheslavsky, Alla, Wallace, Aaron L., Ejemel, Monir, Li, Qi, McMahon, Conor T., Stoppato, Matteo, Giuntini, Serena, Schiller, Zachary A., Pondish, Jessica R., Toomey, Jacqueline R., Schneider, Ryan M., Meisinger, Jordan, Heukers, Raimond, Kruse, Andrew C., Barry, Eileen M., Pierce, Brian G., Klempner, Mark S., Cavacini, Lisa A., Wang, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854682/
https://ncbi.nlm.nih.gov/pubmed/33531570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81895-0
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