Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design

Enterotoxigenic Escherichia coli (ETEC) is estimated to cause approximately 380,000 deaths annually during sporadic or epidemic outbreaks worldwide. Development of vaccines against ETEC is very challenging due to the vast heterogeneity of the ETEC strains. An effective vaccines would have to be mult...

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Foilsithe in:Sci Rep
Main Authors: Amcheslavsky, Alla, Wallace, Aaron L., Ejemel, Monir, Li, Qi, McMahon, Conor T., Stoppato, Matteo, Giuntini, Serena, Schiller, Zachary A., Pondish, Jessica R., Toomey, Jacqueline R., Schneider, Ryan M., Meisinger, Jordan, Heukers, Raimond, Kruse, Andrew C., Barry, Eileen M., Pierce, Brian G., Klempner, Mark S., Cavacini, Lisa A., Wang, Yang
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2021
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854682/
https://ncbi.nlm.nih.gov/pubmed/33531570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81895-0
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