Generation of genetically tailored porcine liver cancer cells by CRISPR/Cas9 editing

Pigs provide a valuable large animal model for several diseases due to their similarity with humans in anatomy, physiology, genetics and drug metabolism. We recently generated a porcine model for TP53(R167H) and KRAS(G12D) driven hepatocellular carcinoma (HCC) by autologous liver implantation. Here...

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Detalhes bibliográficos
Publicado no:Biotechniques
Main Authors: Elkhadragy, Lobna, Regan, Maureen R, M Totura, William, Goli, Kimia Dasteh, Patel, Shovik, Garcia, Kelly, Stewart, Matthew, Schook, Lawrence B, Gaba, Ron C, Schachtschneider, Kyle M
Formato: Artigo
Idioma:Inglês
Publicado em: Future Science Ltd 2020
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852845/
https://ncbi.nlm.nih.gov/pubmed/33222517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2144/btn-2020-0119
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