A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC)

BACKGROUND: Overexpression of epidermal growth factor receptor (EGFR), and downstream pathway activation appears to be a common oncogenic driver in the majority of head and neck squamous cell cancers (HNSCCs); yet targeting EGFR for the treatment of HNSCC has met with limited success. Apart from the...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:EBioMedicine
Κύριοι συγγραφείς: Low, Joo-Leng, Lau, Dawn Pingxi, Zhang, Xiaoqian, Kwang, Xue-Lin, Rohatgi, Neha, Chan, Jane Vin, Chong, Fui-Teen, Wong, Stephen Qi Rong, Leong, Hui-Sun, Thangavelu, Matan Thangavelu, Rikka, Shivaji, Skanderup, Anders Martin Jacobsen, Tan, Daniel Shao Weng, Periyasamy, Giridharan, Koh, Judice Lie Yong, Iyer, N Gopalakrishna, DasGupta, Ramanuj
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Elsevier 2021
Θέματα:
Research Paper
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851772/
https://ncbi.nlm.nih.gov/pubmed/33529999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103220
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