CD8 T Cells Show Protection against Highly Pathogenic Simian Immunodeficiency Virus (SIV) after Vaccination with SIV Gene-Expressing BCG Prime and Vaccinia Virus/Sendai Virus Vector Boosts

Toward development of a dual vaccine for human immunodeficiency virus type 1 (HIV-1) and tuberculosis infections, we developed a urease-deficient bacillus Calmette-Guérin (BCG) strain Tokyo172 (BCGΔurease) to enhance its immunogenicity. BCGΔurease expressing a simian immunodeficiency virus (SIV) Gag...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Kato, Seiichi, Shida, Hisatoshi, Okamura, Tomotaka, Zhang, Xianfeng, Miura, Tomoyuki, Mukai, Tetsu, Inoue, Makoto, Shu, Tsugumine, Naruse, Taeko K., Kimura, Akinori, Yasutomi, Yasuhiro, Matsuo, Kazuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851566/
https://ncbi.nlm.nih.gov/pubmed/33087465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01718-20
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