Phase I trial of oncolytic adenovirus-mediated cytotoxic and interleukin-12 gene therapy for the treatment of metastatic pancreatic cancer

The safety of oncolytic adenovirus-mediated suicide and interleukin-12 (IL12) gene therapy was evaluated in metastatic pancreatic cancer patients. In this phase I study, a replication-competent adenovirus (Ad5-yCD/mutTK(SR39)rep-hIL-12) expressing yCD/mutTK(SR39) (yeast cytidine deaminase/mutant S39...

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Veröffentlicht in:Mol Ther Oncolytics
Hauptverfasser: Barton, Kenneth N., Siddiqui, Farzan, Pompa, Robert, Freytag, Svend O., Khan, Gazala, Dobrosotskaya, Irina, Ajlouni, Munther, Zhang, Yingshu, Cheng, Jingfang, Movsas, Benjamin, Kwon, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851493/
https://ncbi.nlm.nih.gov/pubmed/33575474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.11.006
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