Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB

Inhibitor of differentiation (ID) proteins dimerize with basic HLH (bHLH) transcription factors, repressing transcription of lineage-specification genes across diverse cellular lineages. ID4 is a key regulator of mammary stem cells; however, the mechanism by which it achieves this is unclear. Here,...

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Publicado en:iScience
Main Authors: Holliday, Holly, Roden, Daniel, Junankar, Simon, Wu, Sunny Z., Baker, Laura A., Krisp, Christoph, Chan, Chia-Ling, McFarland, Andrea, Skhinas, Joanna N., Cox, Thomas R., Pal, Bhupinder, Huntington, Nicholas D., Ormandy, Christopher J., Carroll, Jason S., Visvader, Jane, Molloy, Mark P., Swarbrick, Alexander
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851187/
https://ncbi.nlm.nih.gov/pubmed/33554073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102072
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