Trastuzumab upregulates programmed death ligand-1 expression through interaction with NK cells in gastric cancer

BACKGROUND: The predictive significance of programmed death ligand 1 (PD-L1) for programmed death 1 (PD-1) inhibitors remains unclear in gastric cancer (GC) due to the dynamic alteration by treatments. We aimed to elucidate the effects of trastuzumab (Tmab) on PD-L1 expression in GC. METHODS: PD-L1...

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Veröffentlicht in:Br J Cancer
Hauptverfasser: Yamashita, Kohei, Iwatsuki, Masaaki, Yasuda-Yoshihara, Noriko, Morinaga, Takeshi, Nakao, Yosuke, Harada, Kazuto, Eto, Kojiro, Kurashige, Junji, Hiyoshi, Yukiharu, Ishimoto, Takatsugu, Nagai, Yohei, Iwagami, Shiro, Baba, Yoshifumi, Miyamoto, Yuji, Yoshida, Naoya, Ajani, Jaffer A., Baba, Hideo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851117/
https://ncbi.nlm.nih.gov/pubmed/33100329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-01138-3
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