Assessing Oximetry Response to Chimeric Antigen Receptor T-cell Therapy against Glioma with (19)F MRI in a Murine Model

PURPOSE: To assess the cell-specific, intracellular partial pressure of oxygen (Po(2)) dynamics of both tumor and chimeric antigen receptor (CAR) T cells in a murine immunotherapy model. MATERIALS AND METHODS: Human glioblastoma cells or human T cells were intracellularly labeled with perfluorocarbo...

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Veröffentlicht in:Radiol Imaging Cancer
Hauptverfasser: Chapelin, Fanny, Leach, Benjamin I., Chen, Ruifeng, Lister, Deanne, Messer, Karen, Okada, Hideho, Ahrens, Eric T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Radiological Society of North America 2021
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7850236/
https://ncbi.nlm.nih.gov/pubmed/33575659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1148/rycan.2021200062
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