Inhibition of aerobic glycolysis alleviates sepsis-induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK-regulated autophagy

Metabolism reprogramming influences the severity of organ dysfunction, progression to fibrosis, and development of disease in acute kidney injury (AKI). Previously we showed that inhibition of aerobic glycolysis improved survival rates and protected septic mice from kidney injury. However, the under...

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Vydáno v:Int J Mol Med
Hlavní autoři: Tan, Chuyi, Gu, Jia, Li, Tao, Chen, Huan, Liu, Ke, Liu, Meidong, Zhang, Huali, Xiao, Xianzhong
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849980/
https://ncbi.nlm.nih.gov/pubmed/33448325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2021.4852
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