The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene

The human fetal γ-globin gene is repressed in adulthood through complex regulatory mechanisms involving transcription factors and epigenetic modifiers. Reversing γ-globin repression, or maintaining its expression by manipulating regulatory mechanisms, has become a major clinical goal in the treatmen...

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Veröffentlicht in:Haematologica
Hauptverfasser: Fugazza, Cristina, Barbarani, Gloria, Elangovan, Sudharshan, Marini, Maria Giuseppina, Giolitto, Serena, Font-Monclus, Isaura, Marongiu, Maria Franca, Manunza, Laura, Strouboulis, John, Cantu, Claudio, Gasparri, Fabio, Barabino, Silvia M.L., Nakamura, Yukio, Ottolenghi, Sergio, Moi, Paolo, Ronchi, Antonella Ellena
Format: Artigo
Sprache:Inglês
Veröffentlicht: Fondazione Ferrata Storti 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849756/
https://ncbi.nlm.nih.gov/pubmed/32107331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.241224
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