Phenotyping Study of Cyclophosphamide 4-Hydroxylation in Malay Cancer Patients

BACKGROUND: Cyclophosphamide (CP) is an anticancer alkylating group (nitrogen mustard) and a prodrug that will be metabolized to form its active metabolite, 4-hydroxycyclophosphamide (4-OHCP). The various enzymes involved in its bioactivation can cause a wide range of CP expression and activity amon...

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Bibliografische gegevens
Gepubliceerd in:Drug Des Devel Ther
Hoofdauteurs: Hasanah, Yesi Ihdina Fityatal, Harahap, Yahdiana, Purwanto, Denni Joko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Dove 2021
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849187/
https://ncbi.nlm.nih.gov/pubmed/33536743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S279128
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