Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology

BACKGROUND: Genome-wide association studies have established clusterin (CLU) as a genetic modifier for late-onset Alzheimer’s disease (AD). Both protective and risk alleles have been identified which may be associated with its expression levels. However, the physiological function of clusterin in th...

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Publicado en:Mol Neurodegener
Main Authors: Chen, Fading, Swartzlander, Dan B., Ghosh, Anamitra, Fryer, John D., Wang, Baiping, Zheng, Hui
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2021
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849119/
https://ncbi.nlm.nih.gov/pubmed/33517893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00426-7
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