In Vivo Efficacy and Metabolism of the Antimalarial Cycleanine and Improved In Vitro Antiplasmodial Activity of Semisynthetic Analogues

Bisbenzylisoquinoline (BBIQ) alkaloids are a diverse group of natural products that demonstrate a range of biological activities. In this study, the in vitro antiplasmodial activity of three BBIQ alkaloids (cycleanine [compound 1], isochondodendrine [compound 2], and 2′-norcocsuline [compound 3]) is...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Uche, Fidelia Ijeoma, Guo, Xiaozhen, Okokon, Jude, Ullah, Imran, Horrocks, Paul, Boateng, Joshua, Huang, Chenggang, Li, Wen-Wu
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2021
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7848973/
https://ncbi.nlm.nih.gov/pubmed/33257443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01995-20
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