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Oligomer β-amyloid Induces Hyperactivation of Ras to Impede NMDA Receptor-Dependent Long-Term Potentiation in Hippocampal CA1 of Mice
The activity of Ras, a small GTPase protein, is increased in brains with Alzheimer’s disease. The objective of this study was to determine the influence of oligomeric Aβ(1-42) on the activation of Ras, and the involvement of the Ras hyperactivity in Aβ(1-42)-induced deficits in spatial cognition and...
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| Publicado no: | Front Pharmacol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7848859/ https://ncbi.nlm.nih.gov/pubmed/33536910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.595360 |
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