Healthy cells functionally present TAP-independent SSR1 peptides: implications for selection of clinically relevant antigens

Tumors with an impaired transporter associated with antigen processing (TAP) present several endoplasmic reticulum-derived self-antigens on HLA class I (HLA-I) which are absent on healthy cells. Selection of such TAP-independent antigens for T cell-based immunotherapy should include analysis of thei...

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Publicado en:iScience
Autores principales: de Waard, Antonius A., Verkerk, Tamara, Hoefakker, Kelly, van der Steen, Dirk M., Jongsma, Marlieke L.M., Melamed Kadosh, Dganit, Bliss, Sophie, de Ru, Arnoud H., Admon, Arie, van Veelen, Peter A., Griffioen, Marieke, Heemskerk, Mirjam H.M., Spaapen, Robbert M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7847959/
https://ncbi.nlm.nih.gov/pubmed/33554062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102051
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