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Top-Down Characterization of Denatured Proteins and Native Protein Complexes Using Electron Capture Dissociation Implemented within a Modified Ion Mobility-Mass Spectrometer

Electron-based fragmentation methods have revolutionized biomolecular mass spectrometry, in particular native and top-down protein analysis. Here, we report the use of a new electromagnetostatic cell to perform electron capture dissociation (ECD) within a quadrupole/ion mobility/time-of-flight mass...

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發表在:Anal Chem
Main Authors: Williams, Jonathan P., Morrison, Lindsay J., Brown, Jeffery M., Beckman, Joseph S., Voinov, Valery G., Lermyte, Frederik
格式: Artigo
語言:Inglês
出版: 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7847745/
https://ncbi.nlm.nih.gov/pubmed/31999103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.9b04763
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