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A naturally derived small molecule NDSM253 inhibits IKK1 to suppress inflammation response and promote bone healing after fracture

Bone fracture induces an acute inflammatory response in the resident and peripheral monocyte/macrophage cells. Excessive amounts of proinflammatory cytokines can cause severe tissue damage and inhibit bone healing. The proinflammatory cytokine genes are mainly controlled by TLR4/NF-κB (Toll-like rec...

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Dades bibliogràfiques
Publicat a:Am J Transl Res
Autors principals: Shen, Liqi, Xiao, Yun, Xie, Hui, Zhao, Hongbin, Luo, Tao, Liu, Lin, Pan, Xuekun
Format: Artigo
Idioma:Inglês
Publicat: e-Century Publishing Corporation 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7847520/
https://ncbi.nlm.nih.gov/pubmed/33527006
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