Gene therapy via canalostomy approach preserves auditory and vestibular functions in a mouse model of Jervell and Lange-Nielsen syndrome type 2

Mutations in voltage-gated potassium channel KCNE1 cause Jervell and Lange-Nielsen syndrome type 2 (JLNS2), resulting in congenital deafness and vestibular dysfunction. We conducted gene therapy by injecting viral vectors using the canalostomy approach in Kcne1(−/−) mice to treat both the hearing an...

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Foilsithe in:Nat Commun
Main Authors: Wu, Xuewen, Zhang, Li, Li, Yihui, Zhang, Wenjuan, Wang, Jianjun, Cai, Cuiyun, Lin, Xi
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2021
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846845/
https://ncbi.nlm.nih.gov/pubmed/33514733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20808-7
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