Alkannin-Induced Oxidative DNA Damage Synergizes With PARP Inhibition to Cause Cancer-Specific Cytotoxicity

Background: Oncogenic transformation is associated with elevated oxidative stress that promotes tumor progression but also renders cancer cells vulnerable to further oxidative insult. Agents that stimulate ROS generation or suppress antioxidant systems can drive oxidative pressure to toxic levels se...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Chang, Mingxin, Wang, Hongge, Niu, Jiajing, Song, Yan, Zou, Zhihua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844861/
https://ncbi.nlm.nih.gov/pubmed/33519476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.610205
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