Inhibition of Carbonic Anhydrase IX by Ureidosulfonamide Inhibitor U104 Reduces Prostate Cancer Cell Growth, But Does Not Modulate Daunorubicin or Cisplatin Cytotoxicity

Carbonic anhydrase (CA) IX has emerged as a promising target for cancer therapy. It is highly upregulated in hypoxic regions and mediates pH regulation critical for tumor cell survival as well as extracellular acidification of the tumor microenvironment, which promotes tumor aggressiveness via vario...

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Publicado en:Oncol Res
Autores principales: Riemann, Anne, Güttler, Antje, Haupt, Verena, Wichmann, Henri, Reime, Sarah, Bache, Matthias, Vordermark, Dirk, Thews, Oliver
Formato: Artigo
Lenguaje:Inglês
Publicado: Cognizant Communication Corporation 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844713/
https://ncbi.nlm.nih.gov/pubmed/28631600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3727/096504017X14965111926391
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