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Puf4 Mediates Post-transcriptional Regulation of Cell Wall Biosynthesis and Caspofungin Resistance in Cryptococcus neoformans

The human fungal pathogen Cryptococcus neoformans is intrinsically resistant to the echinocandin antifungal drug caspofungin, which targets the β-1,3-glucan synthase encoded by FKS1. Echinocandins have been on the market for 20 years, yet they are the newest class of antifungal drugs. Analysis of a...

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Pubblicato in:mBio
Autori principali: Kalem, Murat C., Subbiah, Harini, Leipheimer, Jay, Glazier, Virginia E., Panepinto, John C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844544/
https://ncbi.nlm.nih.gov/pubmed/33436441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03225-20
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