Transcriptional coupling and repair of 8-OxoG activate a RecA-dependent checkpoint that controls the onset of sporulation in Bacillus subtilis

During sporulation Bacillus subtilis Mfd couples transcription to nucleotide excision repair (NER) to eliminate DNA distorting lesions. Here, we report a significant decline in sporulation following Mfd disruption, which was manifested in the absence of external DNA-damage suggesting that spontaneou...

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Publicado no:Sci Rep
Main Authors: Suárez, Valeria P., Martínez, Lissett E., Leyva-Sánchez, Hilda C., Valenzuela-García, Luz I., Lara-Martínez, Reyna, Jiménez-García, Luis F., Ramírez-Ramírez, Norma, Obregon-Herrera, Armando, Cuéllar-Cruz, Mayra, Robleto, Eduardo A., Pedraza-Reyes, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844254/
https://ncbi.nlm.nih.gov/pubmed/33510358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82247-8
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