Transcriptional coupling and repair of 8-OxoG activate a RecA-dependent checkpoint that controls the onset of sporulation in Bacillus subtilis

During sporulation Bacillus subtilis Mfd couples transcription to nucleotide excision repair (NER) to eliminate DNA distorting lesions. Here, we report a significant decline in sporulation following Mfd disruption, which was manifested in the absence of external DNA-damage suggesting that spontaneou...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Suárez, Valeria P., Martínez, Lissett E., Leyva-Sánchez, Hilda C., Valenzuela-García, Luz I., Lara-Martínez, Reyna, Jiménez-García, Luis F., Ramírez-Ramírez, Norma, Obregon-Herrera, Armando, Cuéllar-Cruz, Mayra, Robleto, Eduardo A., Pedraza-Reyes, Mario
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844254/
https://ncbi.nlm.nih.gov/pubmed/33510358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82247-8
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