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Epigenetic silencing directs expression heterogeneity of stably integrated multi-transcript unit genetic circuits

We report that epigenetic silencing causes the loss of function of multi-transcript unit constructs that are integrated using CRISPR-Cas9. Using a modular two color reporter system flanked by selection markers, we demonstrate that expression heterogeneity does not correlate with sequence alteration...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Zimak, Jan, Wagoner, Zachary W., Nelson, Nellie, Waechtler, Brooke, Schlosser, Hana, Kopecky, Morgan, Wu, Jie, Zhao, Weian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844226/
https://ncbi.nlm.nih.gov/pubmed/33510302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81975-1
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