Epiregulin (EREG) and Myocardin Related Transcription Factor A (MRTF-A) Form a Feedforward Loop to Drive Hepatic Stellate Cell Activation

Trans-differentiation of quiescent hepatic stellate cells (HSC) into myofibroblast cells is considered the linchpin of liver fibrosis. A myriad of signaling pathways contribute to HSC activation and consequently liver fibrosis. Epidermal growth factor (EGF) family of cytokines signal through the cog...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Dev Biol
Hauptverfasser: Wu, Xiaoyan, Dong, Wenhui, Zhang, Tianyi, Ren, Haozhen, Wang, Jinglin, Shang, Longcheng, Zhu, Zhengyi, Zhu, Wei, Shi, Xiaolei, Xu, Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Cell and Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843934/
https://ncbi.nlm.nih.gov/pubmed/33520984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.591246
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