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Basolateral activation with TLR agonists induces polarized cytokine release and reduces barrier function in RPE in vitro

PURPOSE: Systemic inflammation may be of importance in the development of AMD. RPE cells can recognize danger signals with toll-like receptors (TLR) and may react in a pro-inflammatory manner. In this study, we evaluated the basal and apical secretions of TNFα, IL-6, and IL-1β in primary RPE cells a...

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Foilsithe in:Graefes Arch Clin Exp Ophthalmol
Main Authors: Terheyden, Laura, Roider, Johann, Klettner, Alexa
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer Berlin Heidelberg 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843481/
https://ncbi.nlm.nih.gov/pubmed/32949301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00417-020-04930-2
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