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IL-21 arming potentiates the anti-tumor activity of an oncolytic vaccinia virus in monotherapy and combination therapy

BACKGROUND: Oncolytic viruses (OVs) have shown promise in containing cancer progression in both animal models and clinical trials. How to further improve the efficacy of OVs are intensively explored. Arming OVs with immunoregulatory molecules has emerged as an important means to enhance their oncoly...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Chen, Tianyue, Ding, Xiangqing, Liao, Qibin, Gao, Nan, Chen, Ye, Zhao, Chen, Zhang, Xiaoyan, Xu, Jianqing
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843316/
https://ncbi.nlm.nih.gov/pubmed/33504576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001647
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