Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC–MS/MS method in human serum

BACKGROUND: The present COVID-19 pandemic has prompted worldwide repurposing of drugs. The aim of the present work was to develop and validate a two-dimensional isotope-dilution liquid chromatrography tandem mass spectrometry (ID-LC–MS/MS) method for accurate quantification of remdesivir and its act...

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Publicado en:J Pharm Biomed Anal
Autores principales: Habler, Katharina, Brügel, Mathias, Teupser, Daniel, Liebchen, Uwe, Scharf, Christina, Schönermarck, Ulf, Vogeser, Michael, Paal, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier B.V. 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843035/
https://ncbi.nlm.nih.gov/pubmed/33548872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2021.113935
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