Roflumilast Reduced the IL-18-Induced Inflammatory Response in Fibroblast-Like Synoviocytes (FLS)

[Image: see text] Pro-inflammatory cytokines, such as the IL-18-induced inflammatory response and associated damage in fibroblast-like synoviocytes (FLS), play an important role in the pathogenesis of rheumatoid arthritis (RA). Roflumilast, an inhibitor of phosphodiesterase-4 (PDE-4), has been licen...

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Publicat a:ACS Omega
Autors principals: Zhong, Bing, Guo, Shuanghong, Yang, Zhongai, Han, Li, Du, Junsheng, Chen, Jin, Dun, Xianli, Wang, Guangyong
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2021
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841938/
https://ncbi.nlm.nih.gov/pubmed/33521454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c05281
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