The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives

Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells (PSCs), the major producers of extracellular matrix (ECM), drive the severe stromal/desmoplastic reaction in PDAC. Furtherm...

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Udgivet i:Front Oncol
Main Authors: Wu, Yang, Zhang, Chun, Jiang, Kuirong, Werner, Jens, Bazhin, Alexandr V., D’Haese, Jan G.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841014/
https://ncbi.nlm.nih.gov/pubmed/33520728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.621937
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