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Transition and identification of pathological states in p53 dynamics for therapeutic intervention
We study a minimal model of the stress-driven p53 regulatory network that includes competition between active and mutant forms of the tumor-suppressor gene p53. Depending on the nature and level of the external stress signal, four distinct dynamical states of p53 are observed. These states can be di...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7840995/ https://ncbi.nlm.nih.gov/pubmed/33504910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82054-1 |
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