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MicroRNA-21 Inhibition Suppresses Alveolar M2 Macrophages in an Ovalbumin-Induced Allergic Asthma Mice Model

PURPOSE: MicroRNA-21 (miR-21) influences the Th2 immune pathway by suppressing the expressions of interleukin (IL)-12 and interferon (IFN)-γ. The effects of miR-21 suppression on alveolar macrophage polarization and airway inflammation are not known. METHODS: BALB/c and miR-21 knockout (KO) mice wer...

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Detalhes bibliográficos
Publicado no:Allergy Asthma Immunol Res
Main Authors: Lee, Hwa Young, Hur, Jung, Kang, Ji Young, Rhee, Chin Kook, Lee, Sook Young
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840870/
https://ncbi.nlm.nih.gov/pubmed/33474864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4168/aair.2021.13.2.312
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